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Statements

Subject Item
dbpedia-fr:CD117
rdf:type
dbo:Protein dbo:Biomolecule wikidata:Q8054 wikidata:Q206229 owl:Thing
rdfs:label
KIT CD117 Tyrosinkinase KIT
rdfs:comment
Mast/stem cell growth factor receptor (SCFR), aussi connue sous les noms de proto-oncogene c-Kit, tyrosine-protein kinase Kit ou CD117, est une protéine, codée chez les Humains par le gène KIT situé sur le chromosome 4 humain. De multiples variants de transcription codant différents isoformes ont été trouvés pour ce gène.KIT a été décrit en premier par le biochimiste allemand Axel Ullrich en 1987 comme l’homologue cellulaire de l’oncogène viral de sarcome félin v-kit.
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189865520
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prov:wasDerivedFrom
wikipedia-fr:CD117?oldid=189865520&ns=0
foaf:depiction
n4:Protein_KIT_PDB_1pkg.png
prop-fr:année
2002 2003 2000 2001 2006 2007 2004 2005 2012 1991 1992
prop-fr:auteur
André C, Martin E, Cornu F, et al. Fleischman RA Gupta R, Bain BJ, Knight CL Alai M, Mui AL, Cutler RL, et al. Miettinen M, Lasota J Linnekin D Valent P, Ghannadan M, Hauswirth AW, et al. Spritz RA, Giebel LB, Holmes SA Spritz RA, Droetto S, Fukushima Y Patnaik MM, Tefferi A, Pardanani A Duronio V, Welham MJ, Abraham S, et al. Ashman LK, Cambareri AC, To LB, et al. Vandenbark GR, deCastro CM, Taylor H, et al. Lev S, Yarden Y, Givol D Lasota J, Miettinen M Rönnstrand L Canonico B, Felici C, Papa S Sandberg AA, Bridge JA Larizza L, Magnani I, Beghini A Giebel LB, Strunk KM, Holmes SA, Spritz RA Lennartsson J, Rönnstrand L Kitamura Y, Hirotab S
prop-fr:doi
10.1073 10.1172 10.1097 10.2174 10.1002 10.1053 10.108 10.1159 10.1016 10.1007 10.1152
prop-fr:fonction
*protease binding, *protein tyrosine kinase activity, *transmembrane receptor protein tyrosine kinase activity, *receptor signaling protein tyrosine kinase activity, *stem cell factor receptor activity, *protein binding, *ATP binding, *cytokine binding, *protein homodimerization activity, *metal ion binding
prop-fr:fr
CRK Megakaryocyte-associated tyrosine kinase CD63 DOK1 BCR gene STAT1 CD9 List of genes mutated in pigmented cutaneous lesions PIK3R1 dimère de protéine GRB10 Cytokine receptor récepteur de cytokines CRKL PTPN6 TEC Grb2 SOCS6 MPDZ
prop-fr:journal
Cancer Genet. Cytogenet. Appl. Immunohistochem. Mol. Morphol. Physiol. Rev. Int. J. Hematol. J. Biol. Regul. Homeost. Agents Semin Diagn Pathol Am. J. Med. Genet. J. Clin. Invest. Am. J. Hum. Genet. Blood Current cancer drug targets J. Biol. Chem. Int. J. Biochem. Cell Biol. Cell. Mol. Life Sci. Proc. Natl. Acad. Sci. U.S.A. Oncogene Acta Haematol. Leuk. Lymphoma Curr. Cancer Drug Targ.
prop-fr:lang
en
prop-fr:langue
en
prop-fr:légende
Structure de la protéine KIT, PDB
prop-fr:nom
V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
prop-fr:numéro
2 3 1 6 7 4 5 10 11 15 19 23 25
prop-fr:pages
2535 2924 65 90 91 123 2207 1713 492 10866 261 1259 18021 685 1587 357 1619 1053 205 247 1 30
prop-fr:texte
CD9 MATK BCR TEC
prop-fr:titre
Stem cell factor receptor/c-Kit: from basic science to clinical implications. Human piebald trait resulting from a dominant negative mutant allele of the c-kit membrane receptor gene KIT : a review on expression in normal and neoplastic tissues, and mutations and their clinicopathologic correlation The Kasumi-1 cell line: a t-kit mutant model for acute myeloid leukemia Organization and nucleotide sequence of the human KIT proto-oncogene Kit as a human oncogenic tyrosine kinase Dominant negative and loss of function mutations of the c-kit proto-oncogene in human piebaldism Steel factor stimulates the tyrosine phosphorylation of the proto-oncogene product, p95vav, in human hemopoietic cells KIT and PDGFRA mutations in gastrointestinal stromal tumors Cloning and structural analysis of the human c-kit gene Expression of the YB5.B8 antigen in normal human bone marrow Early signaling pathways activated by c-Kit in hematopoietic cells CD117 Deletion of the KIT and PDGFRA genes in a patient with piebaldism p21ras activation via hemopoietin receptors and c-kit requires tyrosine kinase activity but not tyrosine phosphorylation of p21ras GTPase-activating protein Cytogenetic and molecular genetic abnormalities in systemic mastocytosis Kit: molecule of interest for the diagnosis and treatment of mastocytosis and other neoplastic disorders Genomic organization of the human c-kit gene: evolution of the receptor tyrosine kinase subclass III Signal transduction via the stem cell factor receptor/c-Kit The stem cell factor receptor/c-Kit as a drug target in cancer Signal transduction-associated and cell activation-linked antigens expressed in human mast cells A recombinant ectodomain of the receptor for the stem cell factor retains ligand-induced receptor dimerization and antagonizes SCF-stimulated cellular responses Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors. gastrointestinal stromal tumors
prop-fr:trad
Protein dimer CD9 SOCS6 Cytokine receptor
prop-fr:volume
107 75 78 89 92 44 46 50 61 6 7 13 15 23 31 135 267
prop-fr:chromosome
5
prop-fr:entrezgene
3815 16590
prop-fr:nomEspèce
toutes espèces dbpedia-fr:Homo_sapiens dbpedia-fr:Mus_musculus
prop-fr:omim
164920
prop-fr:pmc
48497 295855 1682440
prop-fr:pmid
1377810 1371879 1279971 11919394 23073628 16475976 16082245 10582339 12072198 1712644 1381360 15621809 1376329 1279499 11388751 17691909 15583854 17193822 12041664 1370874 15526160 1373482 1375232
prop-fr:symbole
KIT
prop-fr:uniprot
P05532 P10721
prop-fr:altsymbols
Kit oncogene C-Kit; CD117; PBT; SCFR KIT
prop-fr:chromosomeEtLocus
4 5
prop-fr:nomenclatureEc
2.7
prop-fr:refseq
NP_000213 NP_001116205
dbo:thumbnail
n4:Protein_KIT_PDB_1pkg.png?width=300
foaf:isPrimaryTopicOf
wikipedia-fr:CD117
dbo:abstract
Mast/stem cell growth factor receptor (SCFR), aussi connue sous les noms de proto-oncogene c-Kit, tyrosine-protein kinase Kit ou CD117, est une protéine, codée chez les Humains par le gène KIT situé sur le chromosome 4 humain. De multiples variants de transcription codant différents isoformes ont été trouvés pour ce gène.KIT a été décrit en premier par le biochimiste allemand Axel Ullrich en 1987 comme l’homologue cellulaire de l’oncogène viral de sarcome félin v-kit.
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