About: dbpedia-fr:Mdm2

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An Entity of Type : wikidata:Q7187, within Data Space : prod-dbpedia.inria.fr associated with source document(s)

Attributes	Values
rdf:type	Thing Biomolecule gene Biomolecule Gene
rdfs:label	Mdm2 (fr) Mdm2 (it) Mdm2 (ja) Mdm2 (pt)
rdfs:comment	Le Mdm2 (pour « murine double minute 2 » est l'E3 ubiquitine ligase responsable de la régulation négative de p53. Son gène est le MDM2 situé sur le chromosome 12 humain est un oncogène. C'est une protéine qui est retrouvée chez l'humain. Elle va ubiquitiniler la protéine p53 (gardienne du génome) et ce faisant, p53 sera dégradé par le complexe du protéasome sans exercer son effet. Une mutation amplificatrice de MDM2 inactive complètement p53 donc les dégâts de l'ADN n'entraineront plus de réparation cellulaire ou d'apoptose ce qui va donner naissance à un cancer. (fr)
rdfs:seeAlso	http://www.genenames.org/data/hgnc_data.php?hgnc_id=6973 http://www.genenames.org/data/hgnc_data.php?match=MDM2 https://www.ncbi.nlm.nih.gov/homologene?term=1793 https://omim.org/entry/164785 http://www.ncbi.nlm.nih.gov/nuccore/NM_001145336 http://www.ncbi.nlm.nih.gov/nuccore/NM_001145337 http://www.ncbi.nlm.nih.gov/nuccore/NM_001145339 http://www.ncbi.nlm.nih.gov/nuccore/NM_001145340 http://www.ncbi.nlm.nih.gov/nuccore/NM_001278462 http://www.ncbi.nlm.nih.gov/nuccore/NM_001367990 http://www.ncbi.nlm.nih.gov/nuccore/NM_002392 http://www.ncbi.nlm.nih.gov/nuccore/NM_006878 http://www.ncbi.nlm.nih.gov/nuccore/NM_006879 http://www.ncbi.nlm.nih.gov/nuccore/NM_006880 http://www.ncbi.nlm.nih.gov/nuccore/NM_006881 http://www.ncbi.nlm.nih.gov/nuccore/NM_006882 http://www.ncbi.nlm.nih.gov/nuccore/NM_032739 http://www.ncbi.nlm.nih.gov/nuccore/XM_006719399 http://www.ncbi.nlm.nih.gov/nuccore/XM_006719400
sameAs	dbr:Mdm2 wikidata:Q18028978 dbpedia-cs:Mdm2 dbpedia-cy:MDM2 dbpedia-es:Mdm2 dbpedia-he:Mdm2 dbpedia-hu:Mdm2 dbpedia-it:Mdm2 dbpedia-ja:Mdm2 dbpedia-pt:Mdm2 http://tt.dbpedia.org/resource/MDM2 dbpedia-uk:MDM2 http://ur.dbpedia.org/resource/چوہا_دہرا_دقیقہ_2 uniprot:geneid/4193 http://rdf.ebi.ac.uk/resource/ensembl/ENSG00000135679 http://rdf.ebi.ac.uk/resource/ensembl/ENST00000258148 http://rdf.ebi.ac.uk/resource/ensembl/ENST00000258149 http://rdf.ebi.ac.uk/resource/ensembl/ENST00000299252 http://rdf.ebi.ac.uk/resource/ensembl/ENST00000311420 http://rdf.ebi.ac.uk/resource/ensembl/ENST00000348801 http://rdf.ebi.ac.uk/resource/ensembl/ENST00000350057 http://rdf.ebi.ac.uk/resource/ensembl/ENST00000360430 http://rdf.ebi.ac.uk/resource/ensembl/ENST00000393410 http://rdf.ebi.ac.uk/resource/ensembl/ENST00000393412 http://rdf.ebi.ac.uk/resource/ensembl/ENST00000393413 http://rdf.ebi.ac.uk/resource/ensembl/ENST00000393415 http://rdf.ebi.ac.uk/resource/ensembl/ENST00000393416 http://rdf.ebi.ac.uk/resource/ensembl/ENST00000393417 http://rdf.ebi.ac.uk/resource/ensembl/ENST00000400501 http://rdf.ebi.ac.uk/resource/ensembl/ENST00000471946 http://rdf.ebi.ac.uk/resource/ensembl/ENST00000478070 http://rdf.ebi.ac.uk/resource/ensembl/ENST00000481186 http://rdf.ebi.ac.uk/resource/ensembl/ENST00000493419 http://rdf.ebi.ac.uk/resource/ensembl/ENST00000496959 http://rdf.ebi.ac.uk/resource/ensembl/ENST00000517852 http://rdf.ebi.ac.uk/resource/ensembl/ENST00000523991 http://rdf.ebi.ac.uk/resource/ensembl/ENST00000536089 http://rdf.ebi.ac.uk/resource/ensembl/ENST00000537182 http://rdf.ebi.ac.uk/resource/ensembl/ENST00000539479 http://rdf.ebi.ac.uk/resource/ensembl/ENST00000540352 http://rdf.ebi.ac.uk/resource/ensembl/ENST00000540709 http://rdf.ebi.ac.uk/resource/ensembl/ENST00000542502 http://rdf.ebi.ac.uk/resource/ensembl/ENST00000543046 http://rdf.ebi.ac.uk/resource/ensembl/ENST00000543323 http://rdf.ebi.ac.uk/resource/ensembl/ENST00000544125 http://rdf.ebi.ac.uk/resource/ensembl/ENST00000544561 http://rdf.ebi.ac.uk/resource/ensembl/ENST00000545204 http://rdf.ebi.ac.uk/resource/ensembl/ENST00000546048 http://rdf.ebi.ac.uk/resource/ensembl/ENST00000665020 http://rdf.ebi.ac.uk/resource/ensembl/ENST00000666617 http://rdf.ebi.ac.uk/resource/ensembl/ENST00000671567 http://g.co/kg/m/09xvjd http://ma-graph.org/entity/2776192174 http://ma-graph.org/entity/2909748413
Wikipage page ID	6908274 (xsd:integer)
Wikipage revision ID	186777157 (xsd:integer)
dbo:wikiPageWikiLink	category-fr:Mort_cellulaire dbpedia-fr:Acide_désoxyribonucléique category-fr:Chromosome_12_humain dbpedia-fr:Chromosome_12_humain dbpedia-fr:Chromosome_minuscule_double dbpedia-fr:MDM4 Dimethylamine dbpedia-fr:Protéasome Ubiquitin ligase
page length (characters) of wiki page	1078 (xsd:nonNegativeInteger)
dct:subject	category-fr:Mort_cellulaire category-fr:Chromosome_12_humain
prop-fr:wikiPageUsesTemplate	dbpedia-fr:Modèle:Portail dbpedia-fr:Modèle:Références dbpedia-fr:Modèle:À_sourcer

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